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1 Found helpful • 142 Pages • Complete Study Notes • Year: Pre-2021 • Previously uploaded under: BIOL1003 - Human Biology
HUMAN BIOLOGY. LECTURE 1: DNA and CHROMOSOMES Objectives to understand: • the evidence that DNA encodes genetic information • the structure of DNA • how DNA is replicated • How information in DNA is transecribed into protein • How DNA is packed into chromosomes • The normal human karyotype and some abnormal karyotypes Genes • What was known 1940-50 o Hereditary “factors” causing different traits; physical nature unknown o Carried on chromosomes o Chromosomes consist of protein and DNA o Proteins→ known as key components of body; 20 amino acids know o DNA known to consist of nucleotides but structure not known o Experiements showed SNA was a hereditary material e.g. injecting live mice with different strains to determine an outcome- the mice injected with s strain died and the mice injected with r strain survived→ the s strain was then treated with different enzymes to destroy different parts of the strain→ in all cases the DNA of heat killed strain was intact hence able to pass onto each cases→ allowing transfer of information → destroying the DNA the ability to become pathogenic was destroyed. • Genes made of DNA • Genes are coded instructions for making everything the body needs, especially proteins • A gene is any given segment along the DNA that encodes instructions that allow the cell to produce a specific product e.g. a protein
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